Minnesota Senator Amy Klobuchar will abandon her candidacy for the 2020 Democratic presidential nomination.
Senator Klobuchar came in a distant sixth place in Saturday's South Carolina primary.
Ms Klobuchar, 59, will join Joe Biden at his Dallas, Texas rally on Monday to endorse the former vice-president, US media report.
The news comes on the heels of fellow moderate Pete Buttigieg suspending his campaign on Sunday.
Despite some strong debate performances and a surprise surge in the early primary voting state of New Hampshire, Ms Klobuchar failed to gain broader traction.
On the campaign trail, the Minnesota senator sold herself to moderate voters as the candidate who could win swing states back for the Democrats. However, her profile was largely eclipsed by centrist rivals Mr Biden, 77, and Mr Buttigieg, 38.
The former South Bend, Indiana, mayor Mr Buttigieg also endorsed Mr Biden for the nomination in an apparent effort to consolidate moderate voters and block the progressive Bernie Sanders, who currently leads the field. Mr Buttigieg and Mr Biden campaigned together in Dallas on Monday night.
Yet another former presidential candidate, Beto O'Rourke, is set to endorse Mr Biden, according to people familiar with his plans.
Earlier on Monday, Mr Biden picked up endorsements from former Obama National Security Adviser Susan Rice, US Senators Mark Udall and Tammy Duckworth, and former Senate leader Harry Reid.
Ms Klobuchar's withdrawal comes on the eve of the so-called Super Tuesday primaries. On Tuesday, 14 US states will cast their votes to determine the Democratic presidential nominee.
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